Abstract:
Tremor is a potentially disabling pathology that affects millions of people. The inferior olive (IO) has been implicated in several types of tremor.
1,
2 In particular, electrical synapses have been shown to be essential for the generation of oscillatory activity in the IO,
3 which may manifest as tremor. In a recent paper,
4 we described how the electrical coupling of non-oscillating cells can generate oscillatory network behavior. Here we apply this dynamic mechanism to the IO and discuss the possible clinical applications...
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